Rapid Sequence Intubation โ protocol & drug dosing
RSI โ Rapid Sequence Intubation
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RSI protocol walkthrough
8-step rapid sequence intubation
โบ
1
Preparation โ Team roles assigned, suction on, BVM (bag-valve-mask) ready, drugs drawn, capnography connected, patient positioned ear-to-sternal notch.
2
Preoxygenation โ 100% Oโ ร 3โ5 min via NRB (non-rebreather mask) or HFNC (high-flow nasal cannula) 15 L/min. Target SpOโ >95% before proceeding.
3
Pretreatment โ Not routine per 2023 SCCM (Society of Critical Care Medicine) guidelines. Consider only in specific cases (give 3 min before induction): • Fentanyl 2โ3 mcg/kg IV โ elevated ICP without hypotension, aortic dissection, or ischemic heart disease (blunts sympathetic surge) • Lidocaine 1.5 mg/kg IV โ elevated ICP or reactive airway disease; avoid if hypotensive or bradycardic No evidence supports routine pretreatment in all RSI cases.
4
Induction + paralytic โ Administer simultaneously. No BVM ventilation unless SpOโ critically falling. See drug dosing card below.
5
Cricoid pressure โ Apply at induction, release after cuff inflated and confirmed. Use per attending preference (evidence is mixed).
6
Intubation โ Laryngoscopy at ~45 sec. Cuffed ETT (endotracheal tube): men 7.5โ8.0, women 7.0โ7.5. Inflate cuff. Depth: ~23 cm at lip for men, 21 cm for women.
7
Confirmation โ Waveform capnography (gold standard), bilateral breath sounds, CXR (chest X-ray), SpOโ trending up. Document ETT depth at lip.
8
Post-intubation care โ Start sedation + analgesia. Vent: TV (tidal volume) 6โ8 mL/kg IBW (ideal body weight), PEEP (positive end-expiratory pressure) 5, titrate FiOโ. NG (nasogastric) tube, HOB (head of bed) 30ยฐ, restraints per protocol.
Epinephrine 1 mg IV/IO โ give after initial shocks fail Repeat q3โ5 min Amiodarone 300 mg IV/IO (1st dose) โ 150 mg (2nd dose) or Lidocaine 1โ1.5 mg/kg IV/IO (alternative to amiodarone)
โ Continue: CPR 2 min โ rhythm check โ shock if indicated
Consider advanced airway + capnography IO if IV access not rapidly achievable Treat reversible causes (H's & T's)
โ ROSC (return of spontaneous circulation)
Post-cardiac arrest care โ see PCAC algorithm panel below
2025 update: Amiodarone and lidocaine are equivalent alternatives for refractory VF/pVT. No routine calcium, bicarb, or magnesium unless specific indication (hyperK, hypoMg, tox). Do not use vasopressin in place of epi.
Neuroprognostication โฅ72 hrs after ROSC if comatose Multimodal assessment โ exam, EEG, SSEP (somatosensory evoked potentials), imaging, biomarkers
2025 update: TTM (targeted temperature management) now recommends preventing fever and maintaining normothermia rather than active cooling to 32โ36ยฐC for all patients.
Synchronized cardioversion Sedate if conscious See Cardioversion algorithm
No โ Stable
Assess: narrow vs wide QRS? Regular vs irregular?
โ Stable narrow regular (likely SVT)
Vagal maneuvers (Valsalva, carotid massage) first Adenosine 6 mg rapid IV push โ 12 mg ร 2 if no response
โ Stable narrow irregular (AFib/AFlutter)
Rate control: IV beta-blocker or non-DHP CCB (calcium channel blocker) Amiodarone IV for critically ill without preexcitation If <48 hrs + hemodynamically stable: consider cardioversion Anticoagulation per CHAโDSโ-VASc score
โ Stable wide-complex regular (VT or aberrant SVT)
Assume VT until proven otherwise Amiodarone, procainamide, or sotalol IV If uncertain etiology: adenosine 6 mg IV may be diagnostic/therapeutic Expert consultation
โ ๏ธ 2025: Do NOT give verapamil/diltiazem for wide-complex tachycardia. Avoid CCBs, beta-blockers, digoxin, and IV amiodarone in preexcited AFib (risk of VF). AFib cardioversion: โฅ200 J preferred.
Observe & monitor Identify cause Cardiology consult
Yes โ symptomatic
Atropine 1 mg IV bolus Repeat q3โ5 min Max 3 mg total
โ If atropine ineffective or unlikely to work (Mobitz II, 3ยฐ AV (atrioventricular) block)
Transcutaneous pacing โ initiate promptly, increase mA until capture or Dopamine 5โ20 mcg/kg/min IV infusion (titrate, taper slowly) or Epinephrine 2โ10 mcg/min IV infusion
2025 confirmed: Atropine 1 mg bolus (not 0.5 mg). Dopamine 5โ20 mcg/kg/min. Pacing is a rapid escalation step โ don't delay for Mobitz II or 3ยฐ AV block.
Cardiac arrest in pregnant patient โฅ20 wks gestation
โ
High-quality CPR โ standard rate/depth
Manual left uterine displacement (LUD) โ push uterus leftward to relieve aortocaval compression
Defibrillate without delay if shockable rhythm
IV access above diaphragm (arm/neck) if possible
Activate OB (obstetrics) emergency team immediately
โ No ROSC within 4โ5 min of arrest
Perimortem cesarean delivery (PMCD) Goal: delivery within 5 min of arrest onset Do not transport โ perform at bedside Delivery may improve maternal resuscitation by relieving compression
โ
Continue maternal resuscitation post-delivery ROSC outcomes often improve after delivery Neonatal resuscitation team at bedside
Standard ACLS drugs (epi, amiodarone) are used โ do not withhold due to pregnancy. Fetal considerations are secondary to maternal resuscitation.
BLS (basic life support) universal termination rule
Consider stopping resuscitation when ALL are met: โข Arrest not witnessed by EMS or bystander โข No AED (automated external defibrillator) shock delivered before EMS arrival โข No ROSC after 3 full rounds of CPR and rhythm analysis
ALS (advanced life support) termination rule
Consider stopping resuscitation when ALL are met: โข Arrest not witnessed by EMS โข No bystander CPR before EMS โข No ROSC after full ALS resuscitation โข No AED shock delivered
2025 update: ETCOโ (end-tidal COโ) should NOT be used in isolation to terminate resuscitation efforts. Apply TOR (termination of resuscitation) rules based on EMS scope of practice (BLS vs ALS).
Measure lactate โ Re-measure if >2 mmol/L Blood cultures ร 2 โ Before ABX (antibiotics), don't delay Broad-spectrum ABX โ Within 1 hr of recognition Crystalloid 30 mL/kg IV โ If hypotension or lactate โฅ4 Vasopressors โ Norepinephrine 1st line if MAP <65 despite fluids
2021 SSC (Surviving Sepsis Campaign) updates: balanced crystalloid (LR/PlasmaLyte) preferred over NS; IV corticosteroids for ongoing vasopressor requirement; peripheral vasopressor initiation acceptable over delaying for central access. The 2026 SSC guidelines (129 statements) are now available โ see official link.
BEFAST: Balance, Eyes, Face droop, Arm drift, Speech, Time Code Stroke ยท CT (computed tomography) head stat ยท Last known well time
โ
โฌฆ CT head โ Hemorrhagic?
Yes โ Hemorrhagic
Neurosurgery consult Reverse anticoagulation BP (blood pressure) <140 No tPA!
No โ Ischemic
Within 4.5 hrs: tPA (tissue plasminogen activator) 0.9 mg/kg (max 90 mg) 10% bolus, rest over 60 min BP <185/110 required
โ LVO (large vessel occlusion) suspected
Mechanical thrombectomy โ Neurointerventional consult within 24 hrs
โ ๏ธ 2026 AHA/ASA (American Heart Association/American Stroke Association) Ischemic Stroke Guidelines now available โ includes expanded thrombectomy eligibility, updated thrombolysis options, and first-ever pediatric stroke section. See official link below.
1. Fluids first: 1L isotonic crystalloid (LR or PlasmaLyte preferred over NS) over first hour. Then reassess. Reduce rate for elderly, HF (heart failure), renal failure. 2. Potassium: Do NOT start insulin if K+ <3.5 mEq/L โ replace first. If K+ 3.5โ5.0: add KCl 20โ40 mEq/L to fluids. Goal K+ 4โ5 mmol/L. Monitor q2h. 3. Insulin: Start ONLY after K+ โฅ3.5 and after first hour of fluids. Regular insulin 0.1 units/kg/hr IV. Goal: โ glucose 50โ75 mg/dL/hr.
โ When glucose hits 200 mg/dL
Add dextrose to IV fluids (D5W) to allow continued insulin infusion Titrate insulin to maintain glucose 150โ200 mg/dL until ketosis clears 2024 update: mild/uncomplicated moderate DKA โ SQ (subcutaneous) rapid insulin q1โ2h acceptable
Give long-acting SQ insulin 1โ2 hrs BEFORE stopping IV infusion Restart home regimen ยท Endocrinology consult ยท Diabetes education before discharge
โ ๏ธ Key pitfalls: Never skip potassium check before insulin. Don't use anion gap alone for resolution (use BHB). Bicarb not recommended for mild/moderate DKA. SGLT2i users may have euglycemic DKA (normal glucose with acidosis) โ check ketones even if glucose normal.
Acute agitation โ Identify etiology: medical, psychiatric, substance, or undifferentiated Rule out reversible causes: hypoxia, hypoglycemia, head injury, sepsis, withdrawal
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Step 1 โ Verbal de-escalation
Non-confrontational tone ยท Offer choice ยท Reduce stimulation Use if safe and time permits โ don't delay care for critically ill
โ Escalating or immediate safety risk
Preferred combination (ACEP 2024 Level B):
Droperidol 5 mg IM + Midazolam 5 mg IM or Olanzapine 10 mg IM + Midazolam 5 mg IM
Single agent (Level B):
Droperidol 5โ10 mg IM (preferred single agent) or Olanzapine 10 mg IM or Haloperidol 5โ10 mg IM ยฑ lorazepam 2 mg IM
Ketamine (Level C โ safety/rescue):
4โ5 mg/kg IM or 1โ2 mg/kg IV
Reserve for immediate safety threat. Airway equipment required. โ intubation risk.
โ Etiology-specific guidance
Psychiatric / undifferentiated
Antipsychotics preferred Droperidol or olanzapine + benzo if needed
Alcohol/benzo withdrawal or stimulant intox
Benzodiazepines preferred Lorazepam 2 mg IM/IV or midazolam 5 mg IM Avoid antipsychotics alone
โ
Post-sedation monitoring: SpOโ, RR, ECG (QTc for droperidol/haloperidol) Medical workup for underlying cause ยท Psychiatry or addiction consult as indicated
โ ๏ธ Avoid: IV olanzapine + benzo (respiratory depression risk). Don't use haloperidol alone for alcohol withdrawal. "B52" cocktail (Benadryl + Haldol + Ativan) โ increasing evidence this combo causes excess sedation and complications vs newer regimens.
Unresponsive patient โ Activate emergency response + get AED
โ
Check pulse (carotid) โค10 sec + look for breathing simultaneously If no pulse OR unsure: start CPR
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30 compressions : 2 breaths (if no advanced airway) Rate 100โ120/min ยท Depth โฅ2 in (5 cm) ยท Full recoil 1 breath q6 sec if advanced airway in place
โ
AED (automated external defibrillator) arrives โ power on, attach pads Analyze rhythm โ minimize CPR pause to <10 sec
Shockable
Deliver shock Resume CPR immediately 2 min then re-analyze
Not shockable
Resume CPR immediately 2 min then re-analyze Continue until ALS arrives
PALS (pediatric advanced life support) โ algorithms
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Pediatric cardiac arrest
PALS (pediatric advanced life support) โ shockable & non-shockable
โบ
Pediatric cardiac arrest โ No pulse / Unresponsive (infants to puberty)
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High-quality CPR Infant: 2 fingers/thumbs, 1.5 in depth ยท Child: 2 in depth 100โ120/min ยท 15:2 ratio (2 rescuers) or 30:2 (1 rescuer) IO or IV access ยท Attach monitor
Key difference from adult: most pediatric arrest is respiratory in origin โ ensure adequate oxygenation and airway early. Epi dose is weight-based: 0.01 mg/kg (not fixed 1 mg).
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